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23 Jan 2021

Historically, neoadjuvant trials are difficult. But we do see quite a handful over a year, so I think it's worth an multi-institutional effort we need to look at. Our study actually surpassed that. The cool thing about that is that we will incorporate artificial intelligence and develop comprehensive biomarkers. Shilpa Gupta, MD: Yeah, I think the team here is really fantastic. It's really important for us to engage a urologist for these studies, as you know, without the surgeon's enthusiasm and involvement, we really can't be successful and within a year we competed at enrollment. But we want to develop something in small cell with our colleagues like Dr. Omar Mian from rad-onc, who has interest in that as a basic scientist. Shilpa has 4 jobs listed on their profile. We were involved with the phase II trial that we published this year with pembrolizumab, which also showed improvement in progression-free survival. Shilpa has 6 jobs listed on their profile. sometimes shilpa goes by various nicknames including shilpa d gupta, shilpa das gupta and gupta shipa das. How do you see this moving forward? Shilpa Gupta has 2 jobs listed on their profile. Subscribe:    It's a multi-arm trial with the gem-cis as the control arm, and the other two arms have gem-cis and nivolumab and gem-cis-nivolumab plus IDO inhibitor. Shilpa has 8 jobs listed on their profile. Dale Shepard, MD, PhD: Yeah. Shilpa has 2 jobs listed on their profile. Thanks for the opportunity. Shilpa has 2 jobs listed on their profile. Shilpa has 7 jobs listed on their profile. Yeah, I think the team here is really fantastic. Yes, I joined Cleveland Clinic last year in June from University of Minnesota, and my role here is to lead the bladder cancer program. Genitourinary Oncology Research Fellowship Philadelphia, For bladder cancer patients, since majority do get neoadjuvant chemo at academic institutions, especially, we don't offer adjuvant chemotherapy, and the recent trial with atezolizumab adjuvant immunotherapy was negative, which was disappointing. BMS is doing a phase III randomized trial, which we are involved in with the protocol development, so that's called the ENERGIZE trial. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Dale Shepard, MD, PhD: How are you taking the findings of that and transferring that here to what you're doing here at Cleveland Clinic? 2001, Genitourinary Cancers: Bladder Cancer, prostate Cancer, Kidney Cancer, Testicular Cancer, (Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. Right now, the standard of care for urothelial cancer adjuvant setting is evolving. India That was a phase II trial. Have a great day. As you know, most of these bigger trials usually exclude small cell cancers, even though they allow other histologies, as long as there's some urothelial cancer present. That trial is right now in the works, and that's really exciting for me. Don't forget, you can access real-time updates from Cleveland Clinic's Cancer Center experts on our Consult QD website at consultqd.clevelandclinic.org/cancer. How do we get the word out to people who might not be associated with an academic center about what's going on and how we can get those patients involved in some of these trials? Internal Medicine Farmington, Thanks, Dale. Please join us again soon. We will compare the pre- and post-treatment tissues for sequencing, DNA/RNA sequencing, and novel immunologic biomarkers, and then come up with algorithms to predict which patients may respond to therapy and do all patients need chemotherapy. Are they leery to enroll in trials that delay surgery? As such, gifts of substantial value are generally prohibited. There were no grade four or grade five events, no delayed or immediate immune-related adverse events, which affected timing of surgery. Shilpa shilpa | Dudley, England, United Kingdom | Student at University of Wolverhampton | 1 connection | See Shilpa's complete profile on Linkedin and connect See the complete profile on LinkedIn and discover Shilpa’s connections and jobs at similar companies. I know that you've presented some preliminary results from a phase II trial, something called the Bladder Cancer Signal-Seeking Trial at the GU ASCO meeting earlier this year. Do we have any efforts ongoing for different histologies? Certainly people who might be listening may not be associated with a larger institution, and they may be needing to partner with somebody to send patients. Right now, the standard of care for urothelial cancer adjuvant setting is evolving. Not every place has all these good combinations. Summary: shilpa dasgupta is 44 years old and was born on 08 01 1976. shilpa dasgupta currently lives in foster city, ca; in the past shilpa has also lived in thornton co and cedar park tx. PA USA View Shilpa Gupta’s profile on LinkedIn, the world’s largest professional community. But now, for the first time, we saw that maintenance immunotherapy for patients who had complete partial responses or stable disease that improved overall survival, and this was with avelumab. This is really a nice segue to validate these findings in a randomized fashion. Dale Shepard, MD, PhD: What do you think is the biggest key to building what has become a really robust bladder cancer research program here at Cleveland Clinic? How about patients? She completed Hematology-Oncology fellowship at Thomas Jefferson University followed by a Genitourinary Oncology Translational Research fellowship there in Dr. Marja Nevalainen’s laboratory. Hematology-Oncology Washington, In fact, most patients are reading about it and asking us to enroll them on something with immunotherapy, so patients are quite aware of these trials. View Shilpa Gupta’s profile on LinkedIn, the world’s largest professional community. Based on this trial, we actually got the Department of Defense Idea Award for this year, looking at immune biomarkers, like resistance and response biomarkers to immunotherapy. Our goal is to develop novel agents in combination with chemo and immunotherapy trials. No, that's a very valid concern, and in our phase II trial, we showed that there were no delays to surgery. Shilpa Gupta, MD: Yes, absolutely. Those are some of the other directions we're taking in other settings like cisplatin-ineligible setting. More recently at the annual ASCO meeting, we saw that in the maintenance setting in metastatic urothelial cancer, patients who get first-line platinum-based chemotherapy, which is the current standard, anybody who progresses after that, we already have single agent immunotherapy approved. View Shilpa Gupta’s profile on LinkedIn, the world’s largest professional community. See the complete profile on LinkedIn and discover Shilpa’s connections and jobs at similar companies. Dale Shepard, MD, PhD: This concludes this episode of Cancer Advances. But are there going to be other trials that you're looking into with similar approaches to offer to patients, or what does the landscape look like? That's an excellent question, Dale. Certainly this is a trial that's going to answer some important questions, and we won't exactly know this answer for a while. Shilpa Gupta, MD: But we do. Dr. Gupta’s primary research interests are in genitourinary cancers, with a focus on bladder and prostate cancer. For our GU group, we have several lists for everybody out in the community, including urologists and medical oncologists. Shilpa Gupta, M.D. What's next? Dr. Gupta  is active in several professional organizations including the American Society of Clinical Oncology (ASCO), American Urologic Association (AUA), American Association of Cancer Research (AACR), Society of Urologic Oncology (SUO), Society of Immunotherapy for cancer (SITC), Bladder Cancer Advocacy Network (BCAN), Prostate Cancer Foundation (PCF) and the European society of Medical Oncology (ESMO). See the complete profile on LinkedIn and discover Shilpa’s connections and jobs at similar companies. She's here today to discuss clinical trials in bladder cancer. Shilpa has 10 jobs listed on their profile. Shilpa Gupta, MD: Thanks, Dale. See the complete profile on LinkedIn and discover Shilpa’s connections and jobs at similar companies. Cleveland Clinic Cancer Center oncologist Shilpa Gupta, MD discusses promising findings in the treatment of advanced bladder cancer in this week's Cancer Advances podcast. We have the cohort of our trial, the BLASST-1, which is immunotherapy and chemotherapy and Dr. Peter Black, who's a collaborator from Vancouver, he has a cohort of his patients who received only gem-cis chemotherapy and Dr. Andrea Necchi from Italy has done single-agent pembrolizumab trial in the same setting. You've certainly talked about some pretty interesting trials, there's some exciting things happening, so anything you're looking at as the next big break? Hematology-Oncology Milwaukee, View Shilpa Gupta’s profile on LinkedIn, the world’s largest professional community. SHILPA has 6 jobs listed on their profile. Everybody got operated within the eight to 10-week period and other immunotherapy trials have also alleviated this concern. Any keys to involving all the patients that are being seen in our regional practices? View Shilpa Gupta’s profile on LinkedIn, the world’s largest professional community. Would love to. Not every place has all these good combinations. I think all the programs is we're trying to get that outreach because you realize that so many of the patients are not being treated at the primary academic centers. has been recently appointed as a Staff member of the Department of Solid Tumor Oncology of the Cleveland Clinic Taussig Cancer Institute and focuses on genitourinary malignancies. It does seem to be a common question, doesn't it? Yeah, absolutely. But we do. As you know, most of these bigger trials usually exclude small cell cancers, even though they allow other histologies, as long as there's some urothelial cancer present. I find within my short time here, the time to opening trials is improving as we go and I think you would agree with that. This was an investigator-initiated trial that I led. View shilpa gupta’s profile on LinkedIn, the world’s largest professional community. CORONAVIRUS: DELAYS FOR ROUTINE SURGERIES, VISITOR RESTRICTIONS + COVID-19 TESTING. This is really a nice segue to validate these findings in a randomized fashion. What about the more unusual histologies? Cleveland Clinic Cancer Center provides world-class care to patients with cancer and is at the forefront of new and emerging clinical, translational and basic cancer research. View Shilpa Gupta’s profile on LinkedIn, the world’s largest professional community. 2010, Fellowship - Medical College of Wisconsin More recently at the annual ASCO meeting, we saw that in the maintenance setting in metastatic urothelial cancer, patients who get first-line platinum-based chemotherapy, which is the current standard, anybody who progresses after that, we already have single agent immunotherapy approved. shilpa has 1 job listed on their profile. * In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry. Can you maybe tell us a little bit about that study and about the findings and what you told everyone about? Shilpa Gupta, MD: Yes, absolutely. We randomize them to pembro versus cabozantinib and pembro to basically intensify the outcomes and responses in those good patients who we can catch early on, instead of waiting until they progress. Shilpa Gupta, M.D. 9500 Euclid Avenue, Cleveland, Ohio 44195 |. This was an investigator-initiated trial that I led. View Shilpa Gupta’s profile on LinkedIn, the world’s largest professional community. Auf LinkedIn können Sie sich das vollständige Profil ansehen und mehr über die Kontakte von Shilpa Gupta und … I'm your host, Dr. Dale Shepard, a medical oncologist here at Cleveland Clinic, overseeing our Taussig Phase I and Sarcoma Programs. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. View Shilpa Gupta’s profile on LinkedIn, the world's largest professional community. Our patients here know that in any case, even if they don't go on a trial, 12 weeks of chemotherapy is standard, and after that, within six to eight weeks, they get operated upon. Dale Shepard, MD, PhD: It does seem to be a common question, doesn't it? The primary end-point was pathologic down staging to PT1 or below at surgery, and the study was aimed at achieving at least 45% at cystectomy. We currently have that open at Cleveland Clinic. So thanks so much for joining us today. For bladder cancer patients, since majority do get neoadjuvant chemo at academic institutions, especially, we don't offer adjuvant chemotherapy, and the recent trial with atezolizumab adjuvant immunotherapy was negative, which was disappointing. So we are developing something with atezolizumab and cabozantinib, which is a VEGF-inhibitor. DC USA Dale Shepard, MD, PhD: Yeah, and I think the key is just being available, so if people call or send an email and ask if we have something available, to reach out and collaborate with people, so I think that helps. Yes, absolutely. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page. Shilpa Gupta, MD: Yes, absolutely. Because in upper tract it's found that fibroblast growth factor receptor is expressed up to 70 to 80% patients. Our other two sites, which participated, again, had great urology and med-onc team. Yeah, I think that's a great question, and I would love to get involved with some efforts of sending out communication newsletters, or I think this Cancer Advances circulation should help also. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant. Shilpa Gupta, MD: The key, I think, was a great multi-disciplinary team effort. See the complete profile on LinkedIn and discover Shilpa’s connections and jobs at similar companies. Thank you for listening. You will find additional podcast episodes on our website, clevelandclinic.org/canceradvancespodcast. Dr. Gupta obtained her Medical Degree at the Lady Hardinge Medical College in New Delhi, India and completed a residency in Internal Medicine at the University of Connecticut Health Center. Dale Shepard, MD, PhD: Yeah, absolutely. See the complete profile on LinkedIn and discover Shilpa’s connections and jobs at similar companies. Shilpa has 9 jobs listed on their profile. What about things in an adjunct setting, can you tell me a little bit about what we're doing in that setting? Dr. Gupta shares data from the phase II Bladder Cancer Signal Seeking Trial (BLASST-1), recently presented at the American Society of Clinical Oncology’s Genitourinary Cancers Symposium. Based on these findings, this is the only phase II trial, which has shown that nivolumab is safe with chemotherapy. So any time we open a trial, we are sending out mass emails, and that has been helpful so far. Don't forget, you can access real-time updates from Cleveland Clinic's Cancer Center experts on our Consult QD website at consultqd.clevelandclinic.org/cancer. What about the more unusual histologies? Several trials are still ongoing in that field, but we are very proud to be a part of the PROOF 302 trial, on which I'm involved in its development. Dale Shepard, MD, PhD: How do you see this moving forward? She also serves as the ASCO University Review Panel Member and ASCO Daily News/Podcast Sources Member and on the ASCO Item Writing Workshop. See the complete profile on LinkedIn and discover SHILPA’S connections and jobs at similar companies. Shilpa has 1 job listed on their profile. CT USA We had been thinking of this even before these results came out, and I'll be leading a trial with Alliance for the setting of bladder cancer patients who get platinum-based chemo and then who don't progress on it. Yeah. That is something our urologists here at Glickman are very excited about and are referring patients for that. See the complete profile on LinkedIn and discover Shilpa’s connections and jobs at similar companies. Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. In that trial, we are prospectively selecting based on the biomarker. PubMed is a third-party website with no affiliation with Cleveland Clinic.). View the profiles of professionals named "Shilpa Gupta" on LinkedIn. Hematology-Oncology Philadelphia, But we want to develop something in small cell with our colleagues like Dr. Omar Mian from rad-onc, who has interest in that as a basic scientist. Shilpa has 3 jobs listed on their profile. Based on these findings, this is the only phase II trial, which has shown that nivolumab is safe with chemotherapy. She is the author for the AUA core curriculum for penile cancer. You will find additional podcast episodes on our website, clevelandclinic.org/canceradvancespodcast. Is there any particular thing you're looking forward to? Cancer Advances, a Cleveland Clinic podcast for medical professionals, exploring the latest innovative research and clinical advances in the field of oncology. We found that pathologic down staging occurred in 66% patients and complete responses were seen in 49% patients. Please join us again soon. We are right now looking at developing a trial for patients who are not eligible for cisplatin, who usually just undergo cystectomy, although some early trials have shown that single agent immunotherapy may be effective, but that is early data. Right now we want to see how best to achieve pathologic down staging in those patients. PA USA We are right now looking at developing a trial for patients who are not eligible for cisplatin, who usually just undergo cystectomy, although some early trials have shown that single agent immunotherapy may be effective, but that is early data. Faridabad, It's quite exciting. Shilpa has 3 jobs listed on their profile. More recently at the annual ASCO meeting, we saw that in the maintenance setting in metastatic urothelial cancer, patients who get first-line platinum-based chemotherapy, which is the current standard, anybody who progresses after that, we already have single agent immunotherapy approved. Public Health Service-Reportable Financial Conflicts of Interest. Shilpa has 6 jobs listed on their profile. My urology colleagues, especially Dr. Konety, who was the chair there and Dr. Chris Weight were really strong advocates for this trial, and we're making sure that we enroll as many patients on this. Shilpa, can you tell me a little bit about your role here at Cleveland Clinic? Can you maybe tell us a little bit about that study and about the findings and what you told everyone about? So thanks so much for joining us today. It's really taking a step further by adding another immunotherapy agent. Sehen Sie sich das Profil von Shilpa Gupta im größten Business-Netzwerk der Welt an. Dale Shepard, MD, PhD: Well, there really are a lot of exciting things going on in bladder cancer, and I appreciate you highlighting them for me. 2001, Medical Education - Lady Hardinge Medical College India Shilpa has 3 jobs listed on their profile. View Shilpa Gupta Solanki’s profile on LinkedIn, the world’s largest professional community. See the complete profile on LinkedIn and discover Shilpa’s connections and jobs at similar companies. But I think as an institutional-wide effort, it would be good to have a disease-specific flyer go out to these. What have you found, and how have you managed to offset their concerns? As you noted, this is a Bladder Cancer Signal Seeking Trial I. We currently have that open at Cleveland Clinic. She then joined as faculty in the Division of Hematology, Oncology and Transplantation at the Masonic Cancer Center, University of Minnesota in Minneapolis where she also led the Interdisciplinary Solid Tumor Phase 1 Program until June, 2019 prior to joining the Cleveland Clinic. If patients have residual disease, which has invaded the muscle at the time of either nephroureterectomy or cystectomy, and if they expressed the FGFR3 biomarker, then they're randomized to an FGFR3-inhibitor or placebo, which is reasonable as there is really no standard for those patients. View Dr. Shilpa Gupta’s profile on LinkedIn, the world’s largest professional community. Shilpa has 2 jobs listed on their profile. View Shilpa Gupta’s profile on LinkedIn, the world’s largest professional community. You mentioned upper tract disease, and so certainly one of the things we see a lot here at Cleveland Clinic are rare diseases and that's kind of a focus is seeing people who may have more unusual types of cancer. See the complete profile on LinkedIn and discover shilpa’s connections and jobs at similar companies. Subscribe to the podcast on iTunes, GooglePlay, Spotify, SoundCloud, or wherever you listen to podcasts. View Shilpa Gupta’s profile on LinkedIn, the world’s largest professional community. For our GU group, we have several lists for everybody out in the community, including urologists and medical oncologists. But we do see quite a handful over a year, so I think it's worth an multi-institutional effort we need to look at. What do you think is the biggest key to building what has become a really robust bladder cancer research program here at Cleveland Clinic? Shilpa has 8 jobs listed on their profile. Dale Shepard, MD, PhD: How about patients? See the complete profile on LinkedIn and discover Shilpa’s connections and jobs at similar companies. I find within my short time here, the time to opening trials is improving as we go and I think you would agree with that. See the complete profile on LinkedIn and discover Shilpa’s connections and jobs at similar companies. In fact, most patients are reading about it and asking us to enroll them on something with immunotherapy, so patients are quite aware of these trials. Those are some of the other directions we're taking in other settings like cisplatin-ineligible setting. Shilpa has 1 job listed on their profile. We are thinking of coming up with a chemo plus immunotherapy trial, just for small cell bladder cancer patients, even though it is rare. She has led several early and late phase clinical trials, including investigator-initiated trials using novel targeted therapies and immunotherapies in genitourinary cancers. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias. Shilpa Gupta, MD: Yeah. I think the big plus here is the patient volume we have the opportunity to put on files. Yeah. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. Dale Shepard, MD, PhD: You mentioned upper tract disease, and so certainly one of the things we see a lot here at Cleveland Clinic are rare diseases and that's kind of a focus is seeing people who may have more unusual types of cancer. has been recently appointed as a Staff member of the Department of Solid Tumor Oncology of the Cleveland Clinic Taussig Cancer Institute and focuses on genitourinary malignancies. Certainly immunotherapy is everyone's interest still, combining with chemotherapy. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Fellowship - Jefferson Medical College of Thomas Jefferson University Her research work has been published in peer-reviewed journals including the Journal of Clinical oncology, Lancet Oncology, Clinical cancer Research , European oncology, among others. That's an excellent question, Dale. Typically, I try to reach out to the ones I know personally to see if they have patients to refer to us. To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Our patients here know that in any case, even if they don't go on a trial, 12 weeks of chemotherapy is standard, and after that, within six to eight weeks, they get operated upon. View Shilpa Gupta’s profile on LinkedIn, the world’s largest professional community. View Shilpa Gupta’s profile on LinkedIn, the world’s largest professional community. See the complete profile on LinkedIn and discover Shilpa’s connections and jobs at similar companies. View Shilpa Gupta’s profile on LinkedIn, the world’s largest professional community. Do we have any efforts ongoing for different histologies? As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education. I think the big plus here is the patient volume we have the opportunity to put on files. View Shilpa Gupta Yadav’s profile on LinkedIn, the world’s largest professional community. Shilpa Gupta, MD: Yes. Dale Shepard, MD, PhD: Cancer Advances, a Cleveland Clinic podcast for medical professionals, exploring the latest innovative research and clinical advances in the field of oncology. We wanted to see if adding immunotherapy to this chemotherapy combination can enhance pathologic responses and survival outcomes, as immunotherapy is widely used in metastatic disease with a great response rate and outcomes. As of 1/6/2021, Dr. Gupta has reported no financial relationship with industry that is applicable to this listing. The podcast on iTunes, GooglePlay, Spotify, SoundCloud, or wherever you listen to Podcasts any time open. Relationship with industry and innovation management, go to our Integrity in innovation page and a of. Shilpa das Gupta and Gupta shipa das horizon for bladder cancer Signal Seeking trial I will! Immune-Related adverse events, which is a collaborator on that and a couple of other folks around the country seen... A common question, does n't it has 2 jobs listed on their profile put on files nice segue validate! Another immunotherapy agent we enrolled 41 patients between February, 2018 and June, with! 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